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- Title
Effect of add-on gabapentin on opioid withdrawal symptoms in opium-dependent patients [corrected] [published erratum appears in ADDICTION 2009 Oct;104(10):1776].
- Authors
Kheirabadi GR; Ranjkesh M; Maracy MR; Salehi M
- Abstract
AIMS: Evaluation of the efficacy of gabapentin in patients undergoing out-patient treatment for opiate withdrawal. DESIGN: A 3-week double-blind, randomized, placebo-controlled trial of adjunctive gabapentin in methadone-assisted detoxification (MAD). SETTING: Specialized Addictive Behaviors Unit, an out-patient unit for the treatment of patients with an addictive disorder serving the city of Isfahan (Iran). PARTICIPANTS: Forty out-patients, 37 males and three females, aged 21-61 years, who met DSM-IV criteria for opiate dependence. INTERVENTION: Random assignment of subjects to receive adjunctive treatment with either gabapentin (900 mg/day) or placebo under double-blind conditions. MEASUREMENTS: Severity of subjective withdrawal symptoms using the Subjective Opiate Withdrawal Scale at six stages. FINDINGS: Despite the superiority of gabapentin on controlling some of withdrawal symptoms, no significant differences were reported between two groups. CONCLUSIONS: Dosage of 900 mg/day of gabapentin is not significantly superior to placebo in controlling opiate withdrawal symptoms.
- Publication
Addiction, 2008, Vol 103, Issue 9, p1495
- ISSN
0965-2140
- Publication type
Journal Article
- DOI
10.1111/j.1360-0443.2008.02248.x