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- Title
Prostate health index (PHI) as a reliable biomarker for prostate cancer: a systematic review and meta-analysis.
- Authors
Agnello, Luisa; Vidali, Matteo; Giglio, Rosaria Vincenza; Gambino, Caterina Maria; Ciaccio, Anna Maria; Lo Sasso, Bruna; Ciaccio, Marcello
- Abstract
Prostate cancer (PCa) represents the second most common solid cancer in men worldwide. In the last decades, the prostate health index (PHI) emerged as a reliable biomarker for detecting PCa and differentiating between non-aggressive and aggressive forms. However, before introducing it in clinical practice, more evidence is required. Thus, we performed a systematic review and meta-analysis for assessing the diagnostic performance of PHI for PCa and for detecting clinically significant PCa (csPCa). Relevant publications were identified by a systematic literature search on PubMed and Web of Science from inception to January 11, 2022. Sixty studies, including 14,255 individuals, met the inclusion criteria for our meta-analysis. The pooled sensitivity and specificity of PHI for PCa detection was 0.791 (95%CI 0.739–0.834) and 0.625 (95%CI 0.560–0.686), respectively. The pooled sensitivity and specificity of PHI for csPCa detection was 0.874 (95%CI 0.803–0.923) and 0.569 (95%CI 0.458–0.674), respectively. Additionally, the diagnostic odds ratio was 6.302 and 9.206, respectively, for PCa and csPCa detection, suggesting moderate to good effectiveness of PHI as a diagnostic test. PHI has a high accuracy for detecting PCa and discriminating between aggressive and non-aggressive PCa. Thus, it could be useful as a biomarker in predicting patients harbouring more aggressive cancer and guiding biopsy decisions.
- Subjects
PROSTATE cancer; PROSTATE cancer prognosis; PROSTATE; META-analysis; BIOMARKERS; CANCER patients; SENSITIVITY &; specificity (Statistics)
- Publication
Clinical Chemistry & Laboratory Medicine, 2022, Vol 60, Issue 8, p1261
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2022-0354