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- Title
The pronounced decline of anti-SARS-CoV-2 spike trimeric IgG and RBD IgG in baseline seronegative individuals six months after BNT162b2 vaccination is consistent with the need for vaccine boosters.
- Authors
Salvagno, Gian Luca; Henry, Brandon M.; Pighi, Laura; De Nitto, Simone; Gianfilippi, Gianluca; Lippi, Giuseppe
- Abstract
The median rate of six month decline of antibodies levels compared to the peak values was 85% (IQR, 80-89%) for anti-SARS-CoV-2 spike trimeric IgG and 93% (IQR, 89-95%) for anti-SARS-CoV-2 RBD IgG, respectively. Keywords: antibodies; COVID-19; immune response; SARS-CoV-2; vaccination EN antibodies COVID-19 immune response SARS-CoV-2 vaccination e29 e31 3 01/07/22 20220115 NES 220115 To the Editor, While novel effective therapies against coronavirus disease 2019 (COVID-19) are being developed and deployed, mass vaccination remains at the heart of national and international campaigns aimed at limiting the spread and the unfavorable consequences of the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic [[1]].
- Subjects
COVID-19; BOOSTER vaccines; COVID-19 vaccines; VACCINATION; MEDICAL personnel
- Publication
Clinical Chemistry & Laboratory Medicine, 2022, Vol 60, Issue 2, pe29
- ISSN
1434-6621
- Publication type
Letter
- DOI
10.1515/cclm-2021-1184