We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Osteopontin: Relation between Adipose Tissue and Bone Homeostasis.
- Authors
De Fusco, Carolina; Messina, Antonietta; Monda, Vincenzo; Viggiano, Emanuela; Moscatelli, Fiorenzo; Valenzano, Anna; Esposito, Teresa; Sergio, Chieffi; Cibelli, Giuseppe; Monda, Marcellino; Messina, Giovanni
- Abstract
Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis.
- Subjects
OSTEOPONTIN; ADIPOSE tissues; BONE physiology; BONE metabolism; HOMEOSTASIS; MORPHOGENESIS
- Publication
Stem Cells International, 2017, p1
- ISSN
1687-966X
- Publication type
Article
- DOI
10.1155/2017/4045238