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- Title
Network pharmacology integrated molecular docking reveals the bioactive components and potential targets of ginseng anti-skin ageing mechanism.
- Authors
Du, L. Y.; Li, G.; Jiang, T.; Chen, C. B.; Zhu, S.; Li, Q.; Wang, E. P.
- Abstract
In this study, we adopted a comprehensive approach to study ginseng's preliminary anti-skin ageing molecular mechanism via network pharmacology integrated molecular docking strategy. The results showed that 15 active components and 70 potential targets of ginseng were obtained through screening. 238 biological process (BP) items, 36 cell composition (CC) items and 57 molecular function (MF) items were shown in 97 signalling pathways. They were obtained by Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Moreover, molecular docking was done to validate the strong binding ability between the core target (AKT1 and PTGS2) and active ingredients (panaxadiol, β-sitosterol, frutinone A and girinimbin). These results proved that ginseng plays a vital role in anti-skin ageing through multiple targets and pathways. Besides, provided a deeper insight into the anti-skin ageing action mechanisms of ginseng.
- Subjects
MOLECULAR docking; MOLECULAR pharmacology; GINSENG; BIOACTIVE compounds; CELLULAR signal transduction; GENE ontology
- Publication
Allelopathy Journal, 2021, Vol 54, Issue 2, p289
- ISSN
0971-4693
- Publication type
Article
- DOI
10.26651/allelo.j/2021-54-2-1365