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- Title
Physical Inactivity and Obesity Underlie the Insulin Resistance of Aging.
- Authors
Amati, Francesca; Dubé, John J.; Coen, Paul M.; Stefanovic-Racic, Maja; Toledo, Frederico G. S.; Goodpaster, Bret H.
- Abstract
OBJECTIVE -- Age-associated insulin resistance may underlie the higher prevalence of type 2 diabetes in older adults. We examined a corollary hypothesis that obesity and level of chronic physical inactivity are the true causes for this ostensible effect of aging on insulin resistance. RESEARCH DESIGN AND METHODS-- We compared insulin sensitivity in 7 younger endurance-trained athletes, 12 older athletes, 11 younger normal-weight subjects, 10 older normal-weight subjects, 15 younger obese subjects, and 15 older obese subjects using a glucose clamp. The nonathletes were sedentary. RESULTS-- Insulin sensitivity was not different in younger endurance-trained athletes versus older athletes, in younger normal-weight subjects versus older normal-weight subjects, or in younger obese subjects versus older obese subjects. Regardless of age, athletes were more insulin sensitive than normal-weight sedentary subjects, who in turn were more insulin sensitive than obese subjects. CONCLUSIONS-- Insulin resistance may not be characteristic of aging but rather associated with obesity and physical inactivity.
- Subjects
INSULIN resistance; AGE factors in disease; PEOPLE with diabetes; DISEASE prevalence; OBESITY; HYPOKINESIA; DISEASES in older people
- Publication
Diabetes Care, 2009, Vol 32, Issue 8, p1547
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc09-0267