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- Title
Clinical impact of <sup>11</sup> C-Pittsburgh compound- B positron emission tomography carried out in addition to magnetic resonance imaging and single-photon emission computed tomography on the diagnosis of Alzheimer's disease in patients with dementia and mild cognitive impairment
- Authors
Omachi, Yoshie; Ito, Kimiteru; Arima, Kunimasa; Matsuda, Hiroshi; Nakata, Yasuhiro; Sakata, Masuhiro; Sato, Noriko; Nakagome, Kazuyuki; Motohashi, Nobutaka
- Abstract
Aims The purpose of this study was to evaluate the clinical impact of addition of [11C]Pittsburgh compound-B positron emission tomography (11 C- PiB PET) on routine clinical diagnosis of Alzheimer's disease ( AD) dementia and mild cognitive impairment ( MCI), and to assess diagnostic agreement between clinical criteria and research criteria of the National Institute on Aging-Alzheimer's Association. Methods The diagnosis in 85 patients was made according to clinical criteria. Imaging examinations, including both magnetic resonance imaging and single-photon emission computed tomography/computed tomography to identify neuronal injury ( NI), and 11 C- PiB PET to identify amyloid were performed, and all subjects were re-categorized according to the research criteria. Results Among 40 patients with probable AD dementia ( ProAD), 37 were NI-positive, 29 were 11 C- PiB-positive, and 27 who were both NI- and 11 C- PiB-positive were categorized as having ' ProAD dementia with a high level of evidence of the AD pathophysiological process'. Among 20 patients with possible AD dementia ( PosAD), 17 were NI-positive, and six who were both NI- and 11 C- PiB-positive were categorized as having ' PosAD with evidence of the AD pathophysiological process'. Among 25 patients with MCI, 18 were NI-positive, 13 were 11 C- PiB-positive, and 10 who were both NI- and 11 C- PiB-positive were categorized as having ' MCI due to AD-high likelihood'. Conclusions Diagnostic concordance between clinical criteria and research criteria may not be high in this study. 11 C- PiB PET may be of value in making the diagnosis of dementia and MCI in cases with high diagnostic uncertainty.
- Subjects
POSITRON emission tomography; MAGNETIC resonance imaging; SINGLE-photon emission computed tomography; ALZHEIMER'S disease diagnosis; DEMENTIA patients; MILD cognitive impairment; ALZHEIMER'S Disease Education &; Referral Center (National Institute on Aging); PATIENTS
- Publication
Psychiatry & Clinical Neurosciences, 2015, Vol 69, Issue 12, p741
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1111/pcn.12326