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- Title
The native ABC-F proteins of Staphylococcus aureus do not contribute to intrinsic resistance against ribosome-targeting antibacterial drugs.
- Authors
Galarion, Luiza H; Trigwell, James; Mohamad, Merianne; Nakamoto, Jose A; Clarke, Justin E; Atkinson, Gemma C; O'Neill, Alex J
- Abstract
Failure to detect a change in susceptibility in individual ABC-F deletion mutants could potentially reflect functional redundancy between the encoded proteins; consequently, we employed the same pIMAYZ constructs to sequentially delete all three ABC-F genes in a single strain of JE2. This pathogen is the prime exponent of acquired antibiotic resistance mediated by ARE ABC-F proteins,[1] and as indicated above, other members of the same genus are known to harbour native ARE ABC-Fs[5]; consequently, it seemed entirely possible that native ABC-Fs participate in intrinsic antibiotic resistance in I S. aureus i .
- Subjects
STAPHYLOCOCCUS aureus; MUPIROCIN; PROTEINS; ENTEROCOCCUS; DRUG resistance in bacteria; DRUGS; DRUG resistance; MICROCOCCACEAE
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2023, Vol 78, Issue 10, p2601
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkad238