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- Title
Synthesis of Aryl(chalcogen‐heteroaryl)methyl Sulfones via Sulfuric Acid‐Promoted Three‐Component Reaction in Water.
- Authors
Kuchukulla, Ratnakar Reddy; Tang, Qinqin; Huang, Youming; He, Ze; Zhou, Lihong; Zeng, Qingle
- Abstract
A facile and efficient three‐component reaction in the presence of Brønsted acid in water was developed to synthesize aryl(chalcogen‐heteroaryl)methyl sulfones in good to very high yields with broad substrate scope. Our protocol is eco‐friendly, metal free, and atom economic. The sulfone products may be efficiently transformed into a bactericidal agent analogue and an aryl heteroaryl ketone.
- Subjects
BRONSTED acids; SULFONES; WATER; KETONES; METALS; SULFURIC acid
- Publication
European Journal of Organic Chemistry, 2020, Vol 2020, Issue 26, p4004
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202000547