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- Title
Selective Cyanoalkylation and [2+2+2] Annulation of 1,6‐Enynes with Azobis(alkylcarbonitriles) under Mild Conditions.
- Authors
Kang, Qing‐Qing; Liu, Yi; Huang, Xun‐Jie; Li, Qiang; Wei, Wen‐Ting
- Abstract
In this paper, selective cyanoalkylation and [2+2+2] annulation of 1,6‐enynes with azobis(alkylcarbonitriles) under mild conditions is presented. When the reaction was run in EtOAc without any catalysts or additives, a highly regioselective cyanoalkylation of 1,6‐enynes was achieved. On the other hand, when a mixture of H2O and EtOAc was used as the green reaction medium in the presence of a cheap copper catalyst and an additive, a [2+2+2] annulation of 1,6‐enynes with azobis(isobutyronitrile) (AIBN) and H2O occurred to form four new chemical bonds in one step.
- Subjects
ANNULATION; COPPER catalysts; REGIOSELECTIVITY (Chemistry); CHEMICAL bonds; WATER
- Publication
European Journal of Organic Chemistry, 2019, Vol 2019, Issue 47, p7673
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201901483