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- Title
Combination Rapid-Acting Nicotine Mouth Spray and Nicotine Patch Therapy in Smoking Cessation.
- Authors
Caldwell, Brent O.; Adamson, Simon J.; Crane, Julian
- Abstract
Introduction: Improved smoking cessation rates are urgently required if New Zealand is to reach its target of a smokefree nation by 2025, during which some 600,000 smokers will need to quit. Nicotine replacement therapy remains a core part of the pharmacological approach to smoking cessation. Oral nicotine solutions with rapid onset have recently become available. We have examined the effect of a nicotine spray and a nicotine patch on smoking cessation for 12 months. Methods: We enrolled potential participants—smokers wanting to quit aged 18–70 years, who smoked ≥9 cigarettes per day—with Fagerström Test of Nicotine Dependence score ≥3 in a double-blind trial in 3 trial sites. Smokers were randomized to a nicotine or placebo spray for 6 months, and all received nicotine patches daily for 5 months. They were followed at regular intervals for 12 months. Results: A total of 1,423 subjects were randomized to nicotine oral spray (1mg of nicotine free base per spray) plus nicotine patch or a placebo spray and nicotine patch. The nicotine mouth spray plus nicotine patch showed significant improvements in prolonged abstinence for all measures to 6 months (7 consecutive days at each visit for 6 months: 15.5% vs. 10.6%; p = .006) for the combination versus placebo and nicotine patch. Thereafter, the differences were not significant. Conclusions: The addition of a nicotine mouth spray to a nicotine replacement patch in a population of smokers receiving a low level of behavioral support improved early quitting, but the effects were not sustained.
- Subjects
NEW Zealand; SMOKING cessation; NICOTINE replacement therapy; NICOTINE addiction treatment; SMOKING cessation products; SMOKING policy
- Publication
Nicotine & Tobacco Research, 2014, Vol 16, Issue 10, p1356
- ISSN
1462-2203
- Publication type
Article
- DOI
10.1093/ntr/ntu084