We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites.
- Authors
Sung-Sik Choo; Ee-Seul Kang; Inbeom Song; Donghyun Lee; Jeong-Woo Choi; Tae-Hyung Kim
- Abstract
The detection of dopamine in a highly sensitive and selective manner is crucial for the early diagnosis of a number of neurological diseases/disorders. Here, a report on a new platform for the electrochemical detection of dopamine with a considerable accuracy that comprises a 3D porous graphene oxide (pGO)/gold nanoparticle (GNP)/pGO composite-modified indium tin oxide (ITO) is presented. The pGO was first synthesized and purified by ultrasonication and centrifugation, and it was then further functionalized on the surface of a GNP-immobilized ITO electrode. Remarkably, owing to the synergistic effects of the pGO and GNPs, the 3D pGO-GNP-pGO-modified ITO electrode showed a superior dopamine-detection performance compared with the other pGO- or GNP-modified ITO electrodes. The linear range of the newly developed sensing platform is from 0.1 µM to 30 µM with a limit of detection (LOD) of 1.28 µM, which is more precise than the other previously reported GO-functionalized electrodes. Moreover, the 3D pGO-GNP-pGO-modified ITO electrodes maintained their detection capability even in the presence of several interfering molecules (e.g., ascorbic acid, glucose). The proposed platform of the 3D pGO-GNP-pGO-modified ITO electrode could therefore serve as a competent candidate for the development of a dopamine-sensing platform that is potentially applicable for the early diagnosis of various neurological diseases/disorders.
- Subjects
CHEMICAL detectors; DOPAMINE; INDIUM tin oxide; ELECTRODES; GRAPHENE oxide; DIAGNOSIS of neurological disorders
- Publication
Sensors (14248220), 2017, Vol 17, Issue 4, p861
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s17040861