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- Title
Silent New Brain MRI Lesions in Children with MOG‐Antibody Associated Disease.
- Authors
Fadda, Giulia; Banwell, Brenda; Waters, Patrick; Marrie, Ruth A.; Yeh, E. Ann; O'Mahony, Julia; Arnold, Douglas A.; Bar‐Or, Amit
- Abstract
Anti‐myelin oligodendrocyte glycoprotein immunoglobulin G (MOG‐IgG) antibodies are associated clinically with either a monophasic or relapsing disease course. We investigated the frequency and clinical importance of acquired asymptomatic brain magnetic resonance imaging (MRI) lesions in a prospective incident cohort of 74 MOG‐IgG positive children with serial MRI scans over a median of 5 years from presentation. Silent new lesions were detected in 14% of MOG‐IgG positive participants, most commonly within the first months post‐onset, with a positive predictive value for clinically relapsing disease of only 20%. Detection of asymptomatic lesions alone need not prompt initiation of chronic immunotherapy. ANN NEUROL 2021;89:408–413
- Subjects
BRAIN damage; MAGNETIC resonance imaging; IMMUNOGLOBULIN G; DISEASE relapse; DISEASE progression
- Publication
Annals of Neurology, 2021, Vol 89, Issue 2, p408
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.25957