We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Role of CCR2 in the Development of Streptozotocin-Treated Diabetic Cardiomyopathy.
- Authors
Xin Tan; Lizhi Hu; Zhiping Shu; Long Chen; Xiangrao Li; Meng Du; Dan Sun; Xiaoxiang Mao; Shan Deng; Kai Huang; Fengxiao Zhang; Tan, Xin; Hu, Lizhi; Shu, Zhiping; Chen, Long; Li, Xiangrao; Du, Meng; Sun, Dan; Mao, Xiaoxiang; Deng, Shan
- Abstract
CCR2 has been proven to play an important role in diabetes. However, the role of CCR2 in diabetic cardiomyopathy has not been examined. In this study, we investigated the effects of cardiac CCR2 on diabetic cardiomyopathy. We created a model of streptozotocin (STZ)-induced diabetic cardiomyopathy. Expression of CCR2 was upregulated in the hearts of STZ-induced diabetic mice. CCR2 knockout significantly improved STZ-induced cardiac dysfunction and fibrosis. Moreover, deletion of CCR2 inhibited STZ-induced apoptosis and the production of STZ-induced reactive oxygen species in the heart. CCR2 knockout resulted in M2 polarization in hearts of STZ-treated mice. Treatment with a CCR2 inhibitor reversed hyperglycemia-induced cardiac dysfunction in db/db mice. These results suggest that CCR2-induced inflammation and oxidative stress in the heart are involved in the development of diabetic cardiomyopathy and that CCR2 could be a novel target for therapy.
- Subjects
DIABETIC cardiomyopathy; HEART fibrosis; REACTIVE oxygen species; OXIDATIVE stress; HEART metabolism; ANIMAL experimentation; APOPTOSIS; CELL receptors; COMPARATIVE studies; DIABETES; HEART; HETEROCYCLIC compounds; RESEARCH methodology; MEDICAL cooperation; MICE; RESEARCH; EVALUATION research; FIBROSIS
- Publication
Diabetes, 2019, Vol 68, Issue 11, p2063
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/db18-1231