We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
LIPIN1 Polymorphism Is Associated with Rosiglitazone Response in Patients with Type 2 Diabetes.
- Authors
Eun Seok Kang; Seung Jin Han; Sling Wan Chun; Kyu Yeon Hur; So Hun Kim; Hyun Joo Lee; Chul Woo Ahn; Bong Soo Cha; Hyun Chul Lee
- Abstract
Lipin1 protein is required for normal adipose tissue development and metabolism. Lipin1 is a product of LPIN1 gene (MIM605518) which has been mapped at chromosomes 2p21. Lipin1 deficiency results in the development of immature adipocytes in fatty liver dystrophy in mice and in lipodystrophy in human. Recently, pioglitazone is reported to increase adipocyte lipin1 expression in human. In this study, we evaluate the effects of LPIN polymorphisms on rosiglitazone response in patients with type 2 diabetes (T2DM). A total of 152 T2DM patients were treated with rosiglitazone (4 mg/day) for 12 weeks in addition to their previous medications, which were unchanged. Six single nucleotide polymorphisms (SNPs) at the LPIN1 locus were genotyped: SNP2 (rs11693809, T/C), SNP3 (rs10192566, C/G), SNP4 (rs2278513, T/C), SNP5 (rs2577262, G/A), SNP6 (rs2716610, C/T), and SNP7 (rs1050800, C/T). SNP2, SNP3, and SNP4 are in nearly complete linkage (D' >0.958, r²>0.882). Among the six SNPs tested, only the LPIN SNP3 C/G polymorphism was significantly associated with rosiglitazone treatment response. Patients with G allele in SNP3 showed larger degree of HbA1c decrease with rosiglitazone treatment than those without G allele (1.147 vs. 0.635, p=0.013). Haplotypes were constructed by these 6 SNPS. Haplotype frequencies were 79.234% for TCTXXX and 18.664% for CGCXXX. Patients with CGCXXX haplotype were associated with high amount of HbA1c decrease with rosiglitazone (p=0.014). These data suggest that genetic variations in the LPIN1 gene can affect rosiglitazone treatment response in patients with T2DM.
- Subjects
LIPOPROTEINS; GENETIC polymorphisms; HYPOGLYCEMIC agents; TYPE 2 diabetes; PEOPLE with diabetes; ADIPOSE tissues; HUMAN genetic variation
- Publication
Diabetes, 2007, Vol 56, pA298
- ISSN
0012-1797
- Publication type
Article