We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Adiponectin/Leptin Ratio (ALR) Is Not Associated with Type of Diabetes in Youth After Accounting for Obesity: The SEARCH for Diabetes in Youth Study.
- Authors
Hamman, Richard F.; Dabelea, Dana; D'Agostino Jr., Ralph B.; Dolan, Lawrence; Greenbaum, Carla; Imperatore, Giuseppina; Lawrence, Jean M.; Marcovina, Santica M.; Mayer-Davis, Elizabeth J.; Pihoker, Catherine; Rodriguez, Beatriz L.
- Abstract
Studies suggest that the adiponectin/leptin ratio (ALR) helps to discriminate between type 1 (T1) and type 2 (T2) diabetes (DM) in youth. However, it is not known whether ALR differentiates type after adjusting for obesity. We tested this hypothesits in the SEARCH study, a six-center study of diabetes in US youth aged 0-19 years at diagnosis. SEARCH identified eligible youth with DM in 6 centers prevalent in 2001 or incident in 2002-04; 1,214 participated in a study visit where demographic, anthropometric and clinical data were collected, and plasma adipocytokines were measured. DM type was based on provider assignment. Multiple linear regression was used to estimate mean levels of adipocytokines and ALR, adjusted for multiple factors. The mean age of participants was 11.8 years, 49% were male, 67% were non-Hispanic white, 1,026 had T1 and 188 had T2 DM. As expected, youth with T2 DM had lower adiponectin and higher leptin levels than youth with T1 DM (both p<0.0001). The crude and adjusted mean levels for the ALR are shown in the Table. As previously reported, the crude ALR was significantly higher in youth with T1 versus T2 prior to adjustment. After adjustment for age, sex, and race/ethnicity, the difference was substantially reduced but remained significant. Adjustment for DM duration and HbA1c made little difference. Finally, adjustment for body mass index z-score (normalized to the CDC weight distribution by sex and age) and waist circumference (measures of total and abdominal obesity) showed that the ALR no longer differed by DM type (p=0.11) and was now higher in T2 vs. T1. These results suggest that the ALR is simply a metabolic measure strongly influenced by demographic factors and obesity and does not discriminate etiopathologically between the types of diabetes in youth.
- Subjects
UNITED States; LEPTIN; DIABETES in youth; TYPE 2 diabetes; OBESITY
- Publication
Diabetes, 2007, Vol 56, pA241
- ISSN
0012-1797
- Publication type
Article