We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
miR-140-5p and miR-140-3p: Key Actors in Aging-Related Diseases?
- Authors
Toury, Léa; Frankel, Diane; Airault, Coraline; Magdinier, Frédérique; Roll, Patrice; Kaspi, Elise
- Abstract
microRNAs (miRNAs) are small single strand non-coding RNAs and powerful gene expression regulators. They mainly bind to the 3′UTR sequence of targeted mRNA, leading to their degradation or translation inhibition. miR-140 gene encodes the pre-miR-140 that generates the two mature miRNAs miR-140-5p and miR-140-3p. miR-140-5p/-3p have been associated with the development and progression of cancers, but also non-neoplastic diseases. In aging-related diseases, miR-140-5p and miR-140-3p expressions are modulated. The seric levels of these two miRNAs are used as circulating biomarkers and may represent predictive tools. They are also considered key actors in the pathophysiology of aging-related diseases. miR-140-5p/-3p repress targets regulating cell proliferation, apoptosis, senescence, and inflammation. This work focuses on the roles of miR-140-3p and miR-140-5p in aging-related diseases, details their regulation (i.e., by long non-coding RNA), and reviews the molecular targets of theses miRNAs involved in aging pathophysiology.
- Subjects
LINCRNA; NON-coding RNA; REGULATOR genes; DRUG target; MICRORNA
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 19, p11439
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms231911439