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- Title
GNB3 c.825C>T (rs5443) Polymorphism and Risk of Acute Cardiovascular Events after Renal Allograft Transplant.
- Authors
Peitz, Tobias; Möhlendick, Birte; Siffert, Winfried; Heinemann, Falko Markus; Kribben, Andreas; Eisenberger, Ute; Friebus-Kardash, Justa
- Abstract
The c.825C>T single-nucleotide polymorphism (rs5443) of the guanine nucleotide-binding protein subunit β3 (GNB3) results in increased intracellular signal transduction via G-proteins. The present study investigated the effect of the GNB3 c.825C>T polymorphism on cardiovascular events among renal allograft recipients posttransplant. Our retrospective study involved 436 renal allograft recipients who were followed up for up to 8 years after transplant. The GNB3 c.825C>T polymorphism was detected with restriction fragment length polymorphism (RFLP) polymerase chain reaction (PCR). The GNB3 TT genotype was detected in 43 (10%) of 436 recipients. Death due to an acute cardiovascular event occurred more frequently among recipients with the TT genotype (4 [9%]) than among those with the CC/CT genotypes (7 [2%]; p = 0.003). The rates of myocardial infarction (MI)–free survival (p = 0.003) and acute peripheral artery occlusive disease (PAOD)–free survival (p = 0.004) were significantly lower among T-homozygous patients. A multivariate analysis showed that homozygous GNB3 c.825C>T polymorphism exerted only a mild effect for the occurrence of myocardial infarction (relative risk, 2.2; p = 0.065) or acute PAOD (relative risk, 2.4; p = 0.05) after renal transplant. Our results suggest that the homozygous GNB3 T allele exerts noticeable effects on the risk of MI and acute PAOD only in the presence of additional nonheritable risk factors.
- Subjects
KIDNEY transplantation; G proteins; RESTRICTION fragment length polymorphisms; MYOCARDIAL infarction; PERIPHERAL vascular diseases; SINGLE nucleotide polymorphisms; POLYMERASE chain reaction
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 17, p9783
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23179783