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- Title
Streptomyces sp.—A Treasure Trove of Weapons to Combat Methicillin-Resistant Staphylococcus aureus Biofilm Associated with Biomedical Devices.
- Authors
Pusparajah, Priyia; Letchumanan, Vengadesh; Law, Jodi Woan-Fei; Ab Mutalib, Nurul-Syakima; Ong, Yong Sze; Goh, Bey-Hing; Tan, Loh Teng-Hern; Lee, Learn-Han
- Abstract
Biofilms formed by methicillin-resistant S. aureus (MRSA) are among the most frequent causes of biomedical device-related infection, which are difficult to treat and are often persistent and recurrent. Thus, new and effective antibiofilm agents are urgently needed. In this article, we review the most relevant literature of the recent years reporting on promising anti-MRSA biofilm agents derived from the genus Streptomyces bacteria, and discuss the potential contribution of these newly reported antibiofilm compounds to the current strategies in preventing biofilm formation and eradicating pre-existing biofilms of the clinically important pathogen MRSA. Many efforts are evidenced to address biofilm-related infections, and some novel strategies have been developed and demonstrated encouraging results in preclinical studies. Nevertheless, more in vivo studies with appropriate biofilm models and well-designed multicenter clinical trials are needed to assess the prospects of these strategies.
- Subjects
BIOFILMS; STREPTOMYCES; METHICILLIN-resistant staphylococcus aureus; IN vivo studies; WEAPONS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 17, p9360
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22179360