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- Title
Psoriasis: A STAT3-Centric View.
- Authors
Calautti, Enzo; Avalle, Lidia; Poli, Valeria
- Abstract
Signal Transducer and Activator of Transcription (STAT)3 has recently emerged as a key player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory conditions. Indeed, STAT3 hyperactivation has been reported in virtually every cell type involved in disease initiation and maintenance, and this factor mediates the signal of most cytokines that are involved in disease pathogenesis, including the central Interleukin (IL)-23/IL-17/IL-22 axis. Despite the recent availability of effective biological agents (monoclonal antibodies) against IL-17 and IL-23, which have radically changed the current standard of disease management, the possibility of targeting either STAT3 itself or, even better, the family of upstream activators Janus kinases (JAK1, 2, 3, and TYK2) offers additional therapeutic options. Due to the oral/topical administration modality of these small molecule drugs, their lower cost, and the reduced risk of eliciting adverse immune responses, these compounds are being actively scrutinized in clinical settings. Here, we summarize the main pathological features of psoriatic conditions that provide the rationale for targeting the JAK/STAT3 axis in disease treatment.
- Subjects
PSORIASIS &; genetics; STAT proteins; TRANSCRIPTION factors; CYTOKINES; MONOCLONAL antibodies; IMMUNE response
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 1, p171
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms19010171