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- Title
WNT16B from Ovarian Fibroblasts Induces Differentiation of Regulatory T Cells through β-Catenin Signal in Dendritic Cells.
- Authors
Cong-Cong Shen; Yu-Huan Kang; Ming Zhao; Yi He; Dan-Dan Cui; Yu-Yin Fu; Ling-Lin Yang; Lan-Tu Gou
- Abstract
Treatment for cancer can induce a series of secreted factors into the tumor microenvironment, which can affect cancer progression. Wingless-type MMTV (mouse mammary tumor virus) integration site 16B (WNT16B) is a new member of the WNT family and has been reported to play growth-related roles in previous studies. In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation. We also demonstrated that fibroblast-derived WNT16B could result in accumulation of ß-catenin in dendritic cells and secretion of interleukin-10 (IL-10) and transforming growth factor beta (TGF-ß), which contributed to the differentiation of regulatory T cells in a co-culture environment. These results shed light on the roles of WNT16B in immune regulation, especially in regard to cancer treatment.
- Subjects
FIBROBLASTS; OVARIAN cancer; T cells; CATENINS; DENDRITIC cells; MOUSE mammary tumor virus; CANCER chemotherapy; RADIOTHERAPY
- Publication
International Journal of Molecular Sciences, 2014, Vol 15, Issue 7, p12928
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms150712928