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- Title
An iRGD Based Strategy to Study Electrochemically the Species Inside a Cell.
- Authors
Limin Ning; Xiaoxi Li; Xiaorong Ding; Yongmei Yin; Genxi Li
- Abstract
This paper reports a method for electrical communication between the inner part of cells and an electrode with the help of iRGD peptide. Due to the enhancement of the cell penetration caused by iRGD peptide, DNA molecules, previously modified on a gold electrode surface, can be easily transfected into the cells. At the same time, doxorubicin, an anticancer drug, can also be transfected into cells with high penetration. Consequently, doxorubicin binds to DNA chains through electrostatic interaction, and the redox reaction is transferred out of the cell across the cell membrane. As a result, this work may provide a novel way to get information from inside of cells.
- Subjects
ELECTROCHEMISTRY; SPECIES diversity; CELL membranes; OXIDATION-reduction reaction; ELECTROSTATICS; DOXORUBICIN; DNA; GOLD electrodes; CELL adhesion
- Publication
International Journal of Molecular Sciences, 2012, Vol 13, Issue 8, p10424
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms130810424