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- Title
Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.
- Authors
Balzarini, Jan
- Abstract
Several chronic viral infections (such as HIV and hepatitis C virus) are highly prevalent and are a serious health risk. The adaptation of animal viruses to the human host, as recently exemplified by influenza viruses and the severe acute respiratory syndrome coronavirus, is also a continuous threat. There is a high demand, therefore, for new antiviral lead compounds and novel therapeutic concepts. In this Review, an original therapeutic concept for suppressing enveloped viruses is presented that is based on a specific interaction of carbohydrate-binding agents (CBAs) with the glycans present on viral-envelope glycoproteins. This approach may also be extended to other pathogens, including parasites, bacteria and fungi.
- Subjects
GLYCOPROTEINS; VIRUS diseases; SARS disease; HEPATITIS C virus; MICROORGANISMS
- Publication
Nature Reviews Microbiology, 2007, Vol 5, Issue 8, p583
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro1707