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- Title
para-Selective C-H Amidation of Simple Arenes with Nitriles.
- Authors
Xiang, Shi ‐ Kai; Li, Jin ‐ Mei; Huang, He; Feng, Chun; Ni, Hai ‐ Liang; Chen, Xiao ‐ Zhen; Wang, Bi ‐ Qin; Zhao, Ke ‐ Qing; Hu, Ping; Redshaw, Carl
- Abstract
A para-selective C¢H amidation of simple arenes with nitriles has been developed. By increasing the amount of arenes, a further meta-selective C¢H arylation of the produced amides occurred. Both steric and electronic effects are utilized to control the selectivity, resulting in only para-selective amidation products. The readily available nitriles as amidation reagents instead of amides makes the synthesis of N-arylamides more accessible.
- Subjects
AROMATIC compounds; CATALYSIS; CHEMICAL industry; CHEMICAL reactions; ORGANIC chemistry
- Publication
Advanced Synthesis & Catalysis, 2015, Vol 357, Issue 16/17, p3435
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500651