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- Title
Tandem Synthesis of Amides and Secondary Amines from Esters with Primary Amines under Solvent-Free Conditions.
- Authors
Lee, Jeongbin; Muthaiah, Senthilkumar; Hong, Soon Hyeok
- Abstract
An iridium(III)-catalyzed tandem synthesis of amides and amines from esters under solvent-free conditions is described. A commercially available iridium(III) complex, [Cp*IrCl2]2, with sodium acetate showed the best activity for the synthesis of amides and secondary amines. The amide was formed by ester-amide exchange which generates an alcohol in situ which is subsequently transformed to a secondary amine via hydrogen autotransfer. This synthetic protocol with high atom economy generates water as the sole by-product and can afford amides and amines from various esters in a one-pot reaction, expanding the synthetic versatility of ester transformations.
- Subjects
IRIDIUM catalysts; AMIDES; AMINES; ORGANIC compounds; SODIUM acetate; ESTERS
- Publication
Advanced Synthesis & Catalysis, 2014, Vol 356, Issue 11/12, p2653
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201400319