We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Recovery of T-cell receptor V(D)J recombination reads from lower grade glioma exome files correlates with reduced survival and advanced cancer grade.
- Authors
Chobrutskiy, Boris I.; Zaman, Saif; Tong, Wei Lue; Diviney, Andrea; Blanck, George
- Abstract
Background: The immune system plays an important role in cancer survival and disease progression, but the role of the immune system in lower grade glioma (LGG) is largely unknownMethods: To investigate the relationship between lymphocyte infiltration into the LGG microenvironment and LGG survival, we used a genomics approach to recover productive V(D)J recombination sequences from primary tumor, whole exome sequence files available via the cancer genome atlasResults: Increased T-cell receptor V(D)J read recovery, indicating increased T-lymphocyte infiltration into the primary tumor site, strongly correlated with decreased overall and disease-free survival; and with a more advanced cancer grade. In addition, this result was more significant than related results obtainable using RNASeq-based, T-cell biomarkers, similar to a recently reported case for pancreatic cancer, where the recovery of BCR recombination reads from WXS files clearly associated with reduced survival, despite the fact that no such association was demonstrable with B-cell based, RNASeq biomarkersConclusions: Overall, the results presented here support V(D)J recombination read recovery, from whole exome files, as a uniquely useful biomarker for distinct LGG survival rates.
- Subjects
T-cell receptor genes; GLIOMAS; IMMUNE system; CENTRAL nervous system; TUMOR microenvironment
- Publication
Journal of Neuro-Oncology, 2018, Vol 140, Issue 3, p697
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-018-03001-1