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- Title
A 3D Homochiral MOF [Cd<sub>2</sub>(d-cam)<sub>3</sub>]•2Hdma•4dma for HPLC Chromatographic Enantioseparation.
- Authors
Zhang, Mei; Chen, Xinglian; Zhang, Junhui; Kong, Jiao; Yuan, Liming
- Abstract
Up to now, some chiral metal-organic frameworks (MOFs) have been reported for enantioseparation in . Here we report a homochiral MOF, [Cd2(d-cam)3]·2Hdma·4dma, used as a new chiral stationary phase for high-performance liquid chromatographic enantioseparation. Nine racemates of alcohol, naphthol, ketone, and base compounds were used as analytes for evaluating the separation properties of the chiral MOF packed column. Moreover, some effects such as mobile phase composition, column temperature, and analytes mass for separations on this chiral column also were investigated. The relative standard deviations for the resolution values of run-to-run and column-to-column were less than 2.1% and 3.2%, respectively. The experimental results indicate that the homochiral MOF offered good recognition ability, which promotes the application of chiral MOFs use as stationary phase for enantioseparation. Chirality 28:340-346, 2016. © 2016 Wiley Periodicals, Inc.
- Subjects
METAL-organic frameworks; HIGH performance liquid chromatography; CHIRAL stationary phases; NAPHTHOL; ENANTIOMERS
- Publication
Chirality, 2016, Vol 28, Issue 4, p340
- ISSN
0899-0042
- Publication type
Article
- DOI
10.1002/chir.22588