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- Title
The relationship between nitric oxide and leptin in the lung of rat with streptozotocin-induced diabetes.
- Authors
Oztay, Fusun; Kandil, Asli; Gurel, Ebru; Ustunova, Savas; Kapucu, Aysegul; Balci, Huriye; Akgun-Dar, Kadriye; Demirci, Cihan
- Abstract
Lung structural changes and immunoreactivity of endothelial (eNOS)- and inducible nitric oxide synthase (iNOS) were investigated by light microscopy in lungs of treated and untreated diabetic rats. Diabetes was induced by a single intraperitoneal (i.p.) injection of 65 mg kg−1 streptozotocin (STZ) in Wistar albino male rats. Diabetic rats received daily i.p. doses of dexamethasone (2 mg kg−1), leptin (0.5 µg kg−1) and intramuscular insulin (20 U kg−1) or a combination of these drugs for 1 week starting 4 weeks after the STZ injections. After treatment, the blood levels of glucose, leptin, insulin and nitrate/nitrite (NO
- Publication
Cell Biochemistry & Function, 2008, Vol 26, Issue 2, p162
- ISSN
0263-6484
- Publication type
Article
- DOI
10.1002/cbf.1418