We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
CGRP and migraine: neurogenic inflammation revisited.
- Authors
Geppetti, Pierangelo; Capone, Jay Guido; Trevisani, Marcello; Nicoletti, Paola; Zagli, Giovanni; Tola, Maria Rosalia
- Abstract
For more than a century neurogenic inflammation has been proposed to have a role in various human diseases. The present review will cover the conceptual steps of the itinerary that has led to the conclusion that neurogenic inflammation is important in migraine. Of particular relevance for the object of this article is the observation that tachykin–independent neurogenic inflammatory responses are evident in rodents, but much less pronounced or absent in other mammal species, including man, whereas neurogenic vasodilatation, most likely mediated by CGRP, occurs in most mammalian species and also in man. Recent evidence that a CGRP receptor antagonist was effective in the treatment of migraine attack supports the hypothesis that neurogenic vasodilatation is a major underlying mechanism of migraine.
- Subjects
NEUROLOGY; INFLAMMATION; CALCITONIN gene-related peptide; MIGRAINE; VASODILATION; TRP channels
- Publication
Journal of Headache & Pain, 2005, Vol 6, Issue 2, p61
- ISSN
1129-2369
- Publication type
Article
- DOI
10.1007/s10194-005-0153-6