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- Title
Retrospective analysis of the effectiveness of first-line antiepileptic drugs for generalized onset and unclassified epileptic seizures in Chinese children.
- Authors
Ying-Xue Ding; Li-Ping Zou; Ming-Sheng Ma; Ying Wang; Lu-Liang Meng; Fang Fang; Chang-Hong Ding
- Abstract
Background and purpose: Based on the time until treatment failure, we retrospectively analyzed 389 children to compare the long-term effectiveness of first-line antiepileptic drugs (AEDs) in children with generalized onset or unclassified epileptic seizures. Methods: Analyses were based on time until treatment failure and time until remission. Results: In terms of time until treatment failure, the failure rates of topiramate and carbamazepine were higher than that of sodium valproate ( p < 0.05). For time until 1-year remission, sodium valproate was found to be significantly better than either topiramate or carbamazepine ( p < 0.05). For the subgroup with generalized onset epilepsy, sodium valproate was much better than either topiramate or carbamazepine ( p < 0.05). No significant differences were found between topiramate and carbamazepine ( p = 0.319). For unclassified epileptic seizures, no significant differences were found among the three AEDs. Conclusion: Sodium valproate should be the drug of choice for patients with children with generalized onset, and no significant differences were found among the three AEDs in unclassified epileptic seizures.
- Subjects
ANTICONVULSANTS; CHILDHOOD epilepsy; TREATMENT of epilepsy; TOPIRAMATE; CARBAMAZEPINE
- Publication
Child's Nervous System, 2011, Vol 27, Issue 2, p279
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-010-1255-2