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- Title
Cytotoxic effects of recombinant human biological response modifiers on head and neck carcinoma cells.
- Authors
Zenner, Hans-Peter; Zimmermann, Ulrike; Zenner, H P; Zimmermann, U
- Abstract
The present report shows that the simultaneous application of two biological response modifiers (recombinant human gamma-interferon plus recombinant human alpha-tumor necrosis factor) has a lethal effect on living laryngeal and salivary gland carcinomas. A cytostatic or cytotoxic effect of the two substances alone could only be observed in occasional cases. The results suggest a synergistic action of gamma-interferon and alpha-tumor necrosis factor that might be of therapeutic value for head and neck carcinomas in the future.
- Publication
ORL, 1988, Vol 50, Issue 3, p150
- ISSN
0301-1569
- Publication type
journal article
- DOI
10.1159/000275983