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- Title
Impact of Vancomycin or Linezolid Therapy on Development of Renal Dysfunction and Thrombocytopenia in Japanese Patients.
- Authors
Fujii, Satoshi; Takahashi, Satoshi; Makino, Shinki; Kunimoto, Yusuke; Nakata, Hiromasa; Noda, Norimasa; Sakurai, Koichi; Miyamoto, atsushi
- Abstract
Background: Vancomycin and linezolid therapies are associated with renal dysfunction and thrombocytopenia, respectively. Methods: We retrospectively investigated Japanese patients with renal dysfunction or thrombocytopenia possibly associated with vancomycin and linezolid therapies, including 235 patients treated with parenteral vancomycin and 178 treated with parenteral linezolid. Results: Renal dysfunction occurred more frequently in patients receiving vancomycin (24%) than in those receiving linezolid (13%; p = 0.032), whereas thrombocytopenia occurred more frequently in linezolid-treated patients (41%) than in vancomycin-treated patients (17%; p < 0.001). Controlling trough vancomycin concentrations (<20 μg/ml) protects against renal dysfunction, but thrombocytopenia may occur after >7.5 days of linezolid treatment. Conclusion: Controlling trough vancomycin concentrations to <20 μg/ml protects Japanese patients against renal dysfunction. Linezolid is an appropriate initial therapy for severe infections in patients with acute renal dysfunction, but monitoring of platelet counts is essential after initiation of therapy. © 2014 S. Karger AG, Basel
- Subjects
VANCOMYCIN; LINEZOLID; DRUG side effects; KIDNEY diseases; THROMBOCYTOPENIA; PARENTERAL therapy; PLATELET count
- Publication
Chemotherapy (0009-3157), 2014, Vol 59, Issue 5, p319
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000356756