We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Composite PLA scaffolds reinforced with PDO fibers for tissue engineering.
- Authors
Cont, Liana; Grant, David; Scotchford, Colin; Todea, Milica; Popa, Catalin
- Abstract
Novel composite scaffolds were produced using long continuous bidirectional fibers embedded in an electrospun matrix, with the aim of using them in soft tissue engineering applications. The fibers are of polydioxanone and the matrix of polylactic acid. The novel manufacturing method consists of direct electrospinning performed on both sides of a collector that supports the already arranged fibers. The scaffolds were tested in vitro using 3T3 mouse fibroblasts as-obtained or functionalized with biotin or poly (dopamine). Functionalization did not significantly affect cells attachment, metabolic activity, or proliferation, but poly (dopamine) was proven to be effective in inducing hydrophilicity to the surface.
- Subjects
POLYLACTIC acid; TISSUE scaffolds; TISSUE engineering; ELECTROSPINNING; POLYMERS; BIOTIN
- Publication
Journal of Biomaterials Applications, 2013, Vol 27, Issue 6, p707
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/0885328211423792