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- Title
[<sup>18</sup>F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.
- Authors
Bevan‐Jones, Richard W.; Arnold, Robert; O'Brien, John T.; Cope, Thomas E.; Jones, Simon P.; Passamonti, Luca; Patterson, Karalyn; Rowe, James B.; Hong, Young T.; Fryer, Tim; Aigbirhio, Franklin A.; Coles, Jonathan P.
- Abstract
The PET ligand [18F]AV‐1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with TDP‐43 pathology. Here we assessed [18F]AV‐1451 binding in behavioral variant frontotemporal dementia due to a hexanucleotide repeat expansion in C9orf72, characterized by TDP‐43 pathology. We show that the C9orf72 mutation increases binding in frontotemporal cortex, with a distinctive distribution of binding compared with healthy controls.
- Subjects
FRONTOTEMPORAL dementia; PATHOLOGY; ALZHEIMER'S disease; AUTOPSY; NEURODEGENERATION
- Publication
Annals of Clinical & Translational Neurology, 2018, Vol 5, Issue 10, p1292
- ISSN
2328-9503
- Publication type
Article
- DOI
10.1002/acn3.631