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- Title
Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism.
- Authors
Pulgar, Eduardo; Schwayer, Cornelia; Guerrero, Néstor; López, Loreto; Márquez, Susana; Härtel, Steffen; Soto, Rodrigo; Heisenberg, Carl-Philipp; Concha, Miguel L.
- Abstract
The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development.
- Subjects
PROGENITOR cells; CELL motility; ENDODERM; LATERAL dominance; BRACHYDANIO
- Publication
eLife, 2021, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.66483