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- Title
Associations between smoking and β-cell function in a non-hypertensive and non-diabetic populationSkaraborg Hypertension and Diabetes Project.
- Authors
Östgren, C. J.; Lindblad, U.; Ranstam, J.; Melander, A.; Råstam, L.
- Abstract
SummaryAims An increased risk for Type 2 diabetes in male and female smokers has been associated with insulin resistance. However, this might also be the result of an adverse effect on the β-cell. The aim of the present study was to examine the association between smoking and β-cell function. Methods A community-based, cross-sectional observation study. In 1994, a randomized age-stratified sample of men and women aged ≥ 40 years in the city of Skara, Sweden, were invited to a survey of cardiovascular risk factors. In all, 1109 subjects participated (80%). After the exclusion of subjects with known hypertension or diabetes mellitus, 874 subjects remained to explore. Samples were drawn after an overnight fast. Lifestyle (smoking, physical activity, alcohol consumption) was assessed using a questionnaire. Insulin resistance and insulin secretion were estimated using the homeostasis model assessment (HOMA). Results Cigarette smoking men (n = 101) had a lower HOMA β-cell value (58.1), than never-smokers (n = 158, β-cell value 90.1, P < 0.001). The difference remained with adjustments for age, body mass index, daily alcohol intake and physical exercise habits: 25.9 (95% confidence interval (CI) 9.7–38.8, P = 0.003). Correspondingly, in men the HOMA β-cell value was lower in current smokers than in ex-smokers (difference 24.3, 95% CI 11.1–35.2, P < 0.001). In women, no significant difference appeared in β-cell function vs. different smoking status. There was no association between smoking status and insulin resistance. Conclusions At least in men, smoking may interfere with β-cell function. The prevention of Type 2 diabetes should include strategies to stop smoking.
- Subjects
PANCREATIC beta cells; SMOKING; PEOPLE with diabetes; DIABETES risk factors; HEALTH
- Publication
Diabetic Medicine, 2000, Vol 17, Issue 6, p445
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1046/j.1464-5491.2000.00294.x