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- Title
Tryptophan, an Amino-Acid Endowed with Unique Properties and Its Many Roles in Membrane Proteins.
- Authors
Khemaissa, Sonia; Sagan, Sandrine; Walrant, Astrid
- Abstract
Tryptophan is an aromatic amino acid with unique physico-chemical properties. It is often encountered in membrane proteins, especially at the level of the water/bilayer interface. It plays a role in membrane protein stabilization, anchoring and orientation in lipid bilayers. It has a hydrophobic character but can also engage in many types of interactions, such as π–cation or hydrogen bonds. In this review, we give an overview of the role of tryptophan in membrane proteins and a more detailed description of the underlying noncovalent interactions it can engage in with membrane partners.
- Subjects
MEMBRANE proteins; BILAYER lipid membranes; WATER levels; TRYPTOPHAN; HYDROGEN bonding; AMINO acids
- Publication
Crystals (2073-4352), 2021, Vol 11, Issue 9, p1032
- ISSN
2073-4352
- Publication type
Article
- DOI
10.3390/cryst11091032