We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Extrahypothalamic Corticotropin and α-Melanotropin in Human Brain.
- Authors
Kleber, Gerhard; Gramsch, Christian; Höllt, Volker; Mehraein, Parviz; Pasi, Aurelio; Herz, Albert
- Abstract
The distribution of corticotropin (ACTH) and α-melanotropin (α-MSH) in human brain was investigated by radioimmunoassay using an antiserum which recognized h-ACTH1-39 and α-MSH to an equal degree on a molar basis. Significant amounts of material, which migrated on calibrated Sephadex G-50 columns as synthetic h-ACTH1-39 and synthetic α-MSH, were detected in distinct brain areas. The highest concentrations of ACTH and α-MSH were found in the diencephalon (hypothalamus 4.2 and 12.5 pmol/g wet weight, respectively) and in midbrain (periaqueductal gray 0.5 and 1.7 pmol/g, respectively) and smaller quantities in the rhombencephalon and telencephalon. The ACTH concentration in human pituitary (adenohypophysis) was 104-fold greater than that in the hypothalamus. α-MSH was confined to the midpart and/or stalk region of the pituitary. Copyright © 1980 S. Karger AG, Basel
- Publication
Neuroendocrinology, 1980, Vol 31, Issue 1, p39
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000123048