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- Title
68Ga-DOTA-NOC PET/CT imaging of neuroendocrine tumors: comparison with ¹¹¹In-DTPA-octreotide (OctreoScan®).
- Authors
Krausz, Yodphat; Freedman, Nanette; Rubinstein, Rina; Lavie, Efraim; Orevi, Marina; Tshori, Sagi; Salmon, Asher; Glaser, Benjamin; Chisin, Roland; Mishani, Eyal; Gross, David J.; J Gross, David
- Abstract
<bold>Purpose: </bold>Recent data have indicated that ⁶⁸Ga-DOTA-NOC positron emission tomography/X-ray computed tomography (PET/CT) may yield improved images in a shorter acquisition protocol than ¹¹¹In-DTPA-octreotide (OctreoScan®, OCT). Therefore, we performed a prospective comparison of ⁶⁸Ga-DOTA-NOC and OCT for the detection of neuroendocrine tumors (NETs).<bold>Methods: </bold>Nineteen patients (eight carcinoid, nine pancreatic NETs, and two NE carcinoma of unknown origin) with previous positive OCT scans underwent ⁶⁸Ga-DOTA-NOC PET/CT and OCT single-photon emission computed tomography imaging for staging or follow-up. Findings were compared by region and verified with conventional imaging.<bold>Results: </bold>All images of both modalities demonstrated focal uptake, often at multiple sites. ⁶⁸Ga-DOTA-NOC images were clearer than OCT images, facilitating interpretation. Similar foci were identified with both modalities in 41 regions, with additional foci on ⁶⁸Ga-DOTA-NOC in 21 and on OCT in 15 regions. CT, magnetic resonance imaging, or ultrasound confirmed the concordant findings in 31 of 41 regions and findings seen with ⁶⁸Ga-DOTA-NOC only in 15 of 21 regions. Findings seen with OCT only were less clear and were only confirmed in 4 of 15 regions. ⁶⁸Ga-DOTA-NOC had impact on staging in four patients and on management in three patients.<bold>Conclusions: </bold>Although ⁶⁸Ga-DOTA-NOC and OCT images were similar, in this study, ⁶⁸Ga-DOTA-NOC demonstrated more true positive tumor foci and was better tolerated by patients. This direct comparison supports replacement of OCT with ⁶⁸Ga-DOTA-NOC-PET/CT in the evaluation of NETs.
- Subjects
NEUROENDOCRINE tumors; POSITRON emission tomography; CARCINOID; MAGNETIC resonance imaging; MEDICAL imaging systems; COMPARATIVE studies; COMPUTED tomography; RESEARCH methodology; MEDICAL cooperation; ORGANOMETALLIC compounds; RESEARCH; SOMATOSTATIN; EVALUATION research
- Publication
Molecular Imaging & Biology, 2011, Vol 13, Issue 3, p583
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-010-0374-1