We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers.
- Authors
Lau, Hannah Si Hui; Tan, Veronique Kiak Mien; Tan, Benita Kiat Tee; Sim, Yirong; Quist, Jelmar; Thike, Aye Aye; Tan, Puay Hoon; Pervaiz, Shazib; Grigoriadis, Anita; Sabapathy, Kanaga
- Abstract
Despite our understanding of the genetic basis of intra-tumoral heterogeneity, the role of stromal heterogeneity arising from an altered tumor microenvironment in affecting tumorigenesis is poorly understood. In particular, extensive study on the peri-tumoral stroma in the morphologically normal tissues surrounding the tumor is lacking. Here, we examine the heterogeneity in tumors and peri-tumoral stroma from 8 ER+/PR+/HER2− invasive breast carcinomas, through multi-region transcriptomic profiling by microarray. We describe the regional heterogeneity observed at the intrinsic molecular subtype, pathway enrichment, and cell type composition levels within each tumor and its peri-tumoral region, up to 7 cm from the tumor margins. Moreover, we identify a pro-inflammatory adipose-enriched peri-tumoral subtype which was significantly associated with poorer overall survival in breast cancer patients, in contrast to an adaptive immune cell- and myofibroblast-enriched subtype. These data together suggest that peri-tumoral heterogeneity may be an important determinant of the evolution and treatment of breast cancers.
- Subjects
BREAST cancer; TUMOR microenvironment; OVERALL survival; CANCER patients; HETEROGENEITY
- Publication
NPJ Breast Cancer, 2023, Vol 9, Issue 1, p1
- ISSN
2374-4677
- Publication type
Article
- DOI
10.1038/s41523-023-00590-7