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- Title
Bronşektazide Sistemik İnflamasyon Belirteci; Nötrofil Jelatinaz İlişkili Lipokalin-2.
- Authors
Özyurt, Songül; Özçelik, Neslihan; Kara, Bilge Yılmaz; Arpa, Medeni; Metin, Yavuz; Metin, Nurgül Orhan; Gümüş, Aziz
- Abstract
Objective: Demonstration of increased inflammatory mediators in serum of bronchiectasis patients suggests that systemic inflammation plays an important role in the pathogenesis. The aim of this study is to investigate the relationship between a systemic mediator-Neutrophil Gelatinase Lipocalin-2 (NGAL) and inflammation in patients with bronchiectasis. Material-Method: A total of 50 bronchiectasis patients without acute infection were enrolled. Healthy control group with similar age and gender characteristics consisted of 30 subjects. Peripheral venous blood samples were taken from both the bronchiectasis and the control groups and NGAL levels was measured. At the same time, distribution of bronchiectasis and prevalence were determined by high resolution computed tomography (HRCT). Pulmonary function were also performed. Results: The mean age of the patients was 58 ± 13 and 27(54%) were female. The mean age of the healthy control group was 59 ± 15 years. Lung volumes of the patients with bronchiectasis were as follows; mean FEV1(%): 69±28 and mean FEV1/FVC(%): 74±10. Serum NGAL levels were significantly higher in bronchiectasis group compared to the control group [74.2±24.5 versus 53.3±15.9, respectively (p<0.001)]. There was no significant relationship between serum NGAL levels and the bronchiectasis and other radiological findings detected by HRCT. In addition, no correlation was found between pulmonary function tests and serum NGAL levels. Conclusions: Bronchiectasis is a systemic inflammatory disease and NGAL is a biomarker to indicate this.
- Publication
SDU Journal of Health Science Institute / SDÜ Saglik Bilimleri Enstitüsü Dergisi, 2020, Vol 11, Issue 2, p186
- ISSN
2146-247X
- Publication type
Article
- DOI
10.22312/sdusbed.658668