We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Towards Multiplex Molecular Diagnosis--A Review of Microfluidic Genomics Technologies.
- Authors
Basha, Ismail Hussain Kamal; Wei Ho, Eric Tatt; Yousuff, Caffiyar Mohamed; Hamid, Nor Hisham Bin
- Abstract
Highly sensitive and specific pathogen diagnosis is essential for correct and timely treatment of infectious diseases, especially virulent strains, in people. Point-of-care pathogen diagnosis can be a tremendous help in managing disease outbreaks as well as in routine healthcare settings. Infectious pathogens can be identified with high specificity using molecular methods. A plethora of microfluidic innovations in recent years have now made it increasingly feasible to develop portable, robust, accurate, and sensitive genomic diagnostic devices for deployment at the point of care. However, improving processing time, multiplexed detection, sensitivity and limit of detection, specificity, and ease of deployment in resource-limited settings are ongoing challenges. This review outlines recent techniques in microfluidic genomic diagnosis and devices with a focus on integrating them into a lab on a chip that will lead towards the development of multiplexed point-of-care devices of high sensitivity and specificity.
- Subjects
COMMUNICABLE disease treatment; MICROFLUIDICS; GENOMICS; EQUIPMENT &; supplies
- Publication
Micromachines, 2017, Vol 8, Issue 9, p266
- ISSN
2072-666X
- Publication type
Article
- DOI
10.3390/mi8090266