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- Title
Hydroxytyrosol Dimers from Medicinal Insect Blaps Rynchopetera and the in Vitro Cytotoxic Activity.
- Authors
Pang, Xiu-Qin; Wu, Xiu-Mei; Wang, Qi; Meng, Di; Huang, Yan-Ming; Xu, Jing-Lei; Li, Yue; Liu, Heng; Xiao, Huai; Ding, Zhong-Tao
- Abstract
The edible Blaps rynchopetera Fairmaire is widely used for its various medicinal effects. From its ethyl acetate fraction, three new hydroxytyrosol dimers, rynchopeterine H (1), rynchopeterine I (2) and trans -2-(3,4-dihydroxy-phenyl)-3-hydroxy-7-(2-hydroxyethyl)-1,4-benzdioxane (3), together with four known similar dimers were obtained by chromatography of silica gel and Sephadex LH-20. Their structures were identified by HRESIMS, 1D and 2D NMR spectra analysis. Compounds 1 - 4 were obtained as a mixture, and cytotoxicity screening for HepG2, Caco-2, U251, AGS, B16 and Bel-7402 cell lines showed that the mixture of compounds 1 - 4 exhibited significantly selective cytotoxicity and good inhibitory activity on the proliferation of mouse melanoma cells (B16) with an IC50 value of 27.37 μg·mL−1.
- Subjects
DIMERS; HYDROXYTYROSOL; ETHYL acetate; NORMAL-phase chromatography; INSECTICIDES; INSECTS; SPECTRUM analysis
- Publication
Natural Product Communications, 2022, Vol 17, Issue 3, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X221086906