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- Title
VINCRISTINE AFFECTS THE REDOX REACTIVITY OF HEMOGLOBIN.
- Authors
CÎRJEU, VICTORIA; PUȘCAȘ, CRISTINA; SILAGHI-DUMITRESCU, RADU
- Abstract
The anticancer drug vincristine, known to act by inhibiting tubulin function in human cells, is shown to affect autoxidation rates in hemoglobin – either alone or under conditions where nitrite acts as an initiator in a nitrosative stress cascade. This behavior mirrors those observed by us with four other antitubulin agents - irinotecan, docetaxel, paclitaxel and vinorelbine.
- Subjects
VINCRISTINE; HEMOGLOBINS; TUBULINS; DOCETAXEL; OXIDATION-reduction reaction; ANTINEOPLASTIC agents; PACLITAXEL
- Publication
Studia Universitatis Babes-Bolyai, Chemia, 2021, Vol 66, Issue 2, p325
- ISSN
1224-7154
- Publication type
Article
- DOI
10.24193/subbchem.2021.02.28