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- Title
Safety of Ovarian Tissue Autotransplantation for Cancer Patients.
- Authors
Bockstaele, Laurence; Tsepelidis, Sophie; Dechene, Julie; Englert, Yvon; Demeestere, Isabelle
- Abstract
Cancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent auto transplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technologies. However, human ovarian tissue is generally harvested before the administration of gonadotoxic treatment and could be contaminated with malignant cells. The safety of auto transplantation of ovarian cortex remains a major concern for fertility preservation units worldwide. This paper discusses the main tools for detecting disseminated cancer cells currently available, their limitations, and clinical relevance.
- Subjects
OVARIAN transplantation; AUTOTRANSPLANTATION; OVARIAN cancer treatment; FERTILITY preservation; CANCER cells; CRYOPRESERVATION of organs, tissues, etc.; OVARIAN physiology
- Publication
Obstetrics & Gynecology International, 2012, p1
- ISSN
1687-9589
- Publication type
Article
- DOI
10.1155/2012/495142