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- Title
Fundus autofluorescence imaging in hereditary retinal diseases.
- Authors
Pichi, Francesco; Abboud, Emad B.; Ghazi, Nicola G.; Khan, Arif O.
- Abstract
Abstract: Fundus autofluorescence (FAF) is a non‐invasive retinal imaging modality used in clinical practice to non‐invasively map changes at the level of the retinal pigment epithelium (RPE)/photoreceptor complex and alterations of macular pigment distribution. This imaging method is based on the visualization of intrinsic fluorophores and may be easily and rapidly used in routine patient care. Excessive accumulation of lipofuscin granules in the lysosomal compartment of RPE cells represents a common downstream pathogenic pathway in various hereditary and complex retinal diseases. The clinical applications of FAF continue to expand. It is now an essential tool for evaluating macular dystrophies and various hereditary retinal disorders. Fundus autofluorescence (FAF) may detect abnormalities beyond those detected on funduscopic examination, fluorescein angiography (FA) or optical coherence tomography (OCT). Fundus autofluorescence (FAF) imaging is particularly helpful for differential diagnosis, detection and extent delineation of involved retinal areas, genotype‐phenotype correlations and monitoring of changes overtime. Given its ease of use, non‐invasive nature and value in characterizing retinal disease, FAF enjoys increasing clinical relevance. This review summarizes basic principles and FAF findings in various hereditary retinal diseases.
- Subjects
RETINAL diseases; OPTICAL coherence tomography; RHODOPSIN; EPITHELIUM; PHOTORECEPTORS; FLUOROPHORES
- Publication
Acta Ophthalmologica (1755375X), 2018, Vol 96, Issue 5, pe549
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/aos.13602