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- Title
Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction.
- Authors
Rabaan, Ali A.; AlSaihati, Hajir; Bukhamsin, Rehab; Bakhrebah, Muhammed A.; Nassar, Majed S.; Alsaleh, Abdulmonem A.; Alhashem, Yousef N.; Bukhamseen, Ammar Y.; Al-Ruhimy, Khalil; Alotaibi, Mohammed; Alsubki, Roua A.; Alahmed, Hejji E.; Al-Abdulhadi, Saleh; Alhashem, Fatemah A.; Alqatari, Ahlam A.; Alsayyah, Ahmed; Farahat, Ramadan Abdelmoez; Abdulal, Rwaa H.; Al-Ahmed, Ali H.; Imran, Mohd.
- Abstract
Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing's rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.
- Subjects
CRISPRS; CANCER treatment; MEDICAL technology; INDIVIDUALIZED medicine; ONCOGENIC viruses; CLINICAL trials
- Publication
Current Oncology, 2023, Vol 30, Issue 2, p1954
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3390/curroncol30020152