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- Title
Comparison of functional fibrinogen assessment using thromboelastography with the standard von Clauss method.
- Authors
Fluger, Ivo; Maderova, Katerina; Simek, Martin; Hajek, Roman; Zapletalova, Jana; Lonsky, Vladimir
- Abstract
Aim. To compare assessment of fibrinogen by thromboelastography with the standard von Clauss method. Methods. Observational prospective study. Results. Thromboelastography provides direct and complex evaluation of the entire coagulation cascade based upon changes in blood viscosity. It affects both platelets and plasma components. New application of this method measures fibrinogen contribution to coagulation as opposed to fibrinogen antigen levels measured by immunoassay. Paired samples from 117 patients before cardiopulmonary bypass were compared. A moderate correlation was found between fibrinogen and functional fibrinogen with a Spearman correlation coefficient of 0.476. Conclusion. The functional fibrinogen test is a valid point-of-care method for fibrinogen assay with a moderate correlation to the standard method.
- Subjects
THROMBELASTOGRAPHY; COMPARATIVE studies; FIBRINOGEN; BLOOD viscosity; CARDIOPULMONARY bypass; BLOOD coagulation; IMMUNOASSAY
- Publication
Biomedical Papers of the Medical Faculty of Palacky University in Olomouc, 2012, Vol 156, Issue 3, p260
- ISSN
1213-8118
- Publication type
Article
- DOI
10.5507/bp.2011.035