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- Title
Game-changing insights on vertebral skeletal stem cells in bone metastasis and therapeutic horizons.
- Authors
QIUQIANG CHEN; XIAOLEI ZHAO; WENXUE MA
- Abstract
Greenblatt and his team have unveiled vertebral skeletal stem cells (vSSCs) as a critical player in the landscape of bone metastasis. This commentary delves into the transformative discoveries surrounding vSSCs, emphasizing their distinct role in bone metastasis compared to other stem cell lineages. We illuminate the unique properties and functions of vSSCs, which may account for the elevated susceptibility of vertebral bones to metastatic invasion. Furthermore, we explore the exciting therapeutic horizons opened by this newfound understanding. These include potential interventions targeting vSSCs, modulation of associated signaling pathways, and broader implications for the treatment and management of bone metastasis. By shedding light on these game-changing insights, we hope to pave the way for novel strategies that could revolutionize the prognosis and treatment landscape for cancer patients with metastatic bone disease.
- Subjects
BONE metastasis; STEM cells; BONE cells; STEM cell research; METASTASIS
- Publication
Oncology Research, 2024, Vol 32, Issue 1, p95
- ISSN
0965-0407
- Publication type
Article
- DOI
10.32604/or.2023.046174