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- Title
Cardiopulmonary effects of constant-flow ventilation in experimental myocardial ischaemia.
- Authors
HACHENBERG, T.; MEYER, S.; SIELENKÄMPER, A.; KNICHWITZ, G.; HAVERKAMP, W.; HINDRICKS, G.; WENDT, M.
- Abstract
The cardiopulmonary effects of constant-flow ventilation were investigated in dogs with normal heart function (controlphase, n=14) and after development of acute myocardial ischaemia (ischaeinia phase, n=14). Heated, humidified and oxygen-enriched air was continuously delivered with an inspiratory flow rate of 1·21. kg . min via two catheters positioned within each mainstem bronchus. Continuous positive pressure ventilation with a positive end-expiratory pressure of 0·5 kPa (5 cmHO) swas used as a reference. During control, neither continuous positive pressure ventilation nor constant-flow ventilation showed impairment of cardiopulmonary performance. Oxygenation and CO removal were more efficiently achieved by continuous positive pressure ventilation (≤0·05). Acute myocardial ischaemia was induced by occlusion of the left anterior descending (LAD) coronary artery; measurements during the ischaemia phase were per formed 60 mm following LAD occlusion. Myocardial ischaemia resulted in moderate changes of cardiac output, left ventricular end-diastolic pressure and dP/dt Both modes of ventilation were well tolerated in the ischaemia phase, and cardiovascular performance revealed no significant differences between continuous positive pressure ventilation and constant-flow ventilation. Haemodynamic parameters could be more precisely assessed during constant-flow ventilation. Oxygenation deteriorated, but hypoxaemia did not occur in any animal and CO elimination remained unchanged. It is concluded that ‘non-conventional’ ventilation by continuous intrabronchial gas flow maintains adequate gas exchange with no adverse effects on haemodynamics in dogs with acute myocardial ischaemia. Constant-flow ventilation may be advantageous in the experimental setting to study cardiac function without cyclic heart-lung interaction due to airway pressure alterations.
- Publication
European Heart Journal, 1991, Vol 12, Issue 11, p1163
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/12.11.1163